A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality
| Autor: | José Andrade Gomes, Pedro Póvoa, Rodrigo B. Serafim, Jorge I. F. Salluh |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry MEDLINE 030208 emergency & critical care medicine Critical Care and Intensive Care Medicine medicine.disease Newcastle–Ottawa scale Sepsis Systemic inflammatory response syndrome 03 medical and health sciences 0302 clinical medicine Systematic review Relative risk Meta-analysis Emergency medicine Epidemiology medicine 030212 general & internal medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 153:646-655 |
| ISSN: | 0012-3692 |
| Popis: | Background Several studies were published to validate the quick Sepsis-related Organ Failure Assessment (qSOFA), namely in comparison with the systemic inflammatory response syndrome (SIRS) criteria. We performed a systematic review and meta-analysis with the aim of comparing the qSOFA and SIRS in patients outside the ICU. Methods We searched MEDLINE, CINAHL, and the Web of Science database from February 23, 2016 until June 30, 2017 to identify full-text English-language studies published after the Sepsis-3 publication comparing the qSOFA and SIRS and their sensitivity or specificity in diagnosing sepsis, as well as hospital and ICU length of stay and hospital mortality. Data extraction from the selected studies followed the recommendations of the Meta-analyses of Observational Studies in Epidemiology group and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Results From 4,022 citations, 10 studies met the inclusion criteria. Pooling all the studies, a total of 229,480 patients were evaluated. The meta-analysis of sensitivity for the diagnosis of sepsis comparing the qSOFA and SIRS was in favor of SIRS (risk ratio [RR], 1.32; 95% CI, 0.40-2.24; P Conclusions The SIRS was significantly superior to the qSOFA for sepsis diagnosis, and the qSOFA was slightly better than the SIRS in predicting hospital mortality. The association of both criteria could provide a better model to initiate or escalate therapy in patients with sepsis. Systematic Review Registration PROSPERO CRD42017067645. |
| Databáze: | OpenAIRE |
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