Design and Evaluation of a Rotating Basket-Paddle Dissolution Apparatus

Autor:	Louis N. Ace, Tarun K. Mandal, Charles S. Chiao
Rok vydání:	1994
Předmět:	Pharmacology Chromatography Materials science Pharmaceutical technology Organic Chemistry Drug Discovery technology industry and agriculture Pharmaceutical Science Paddle Dissolution testing ASPIRIN TABLETS equipment and supplies Dissolution
Zdroj:	Drug Development and Industrial Pharmacy. 20:1753-1760
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639049409038391
Popis:	The rotating basket-paddle dissolution apparatus is a combination of the USP/NF rotating basket and rotating paddle. A comparative dissolution study was performed utilizing this new apparatus and the two USP/NF apparatus at various stirring speeds using non-disintegrating oxalic acid tablets and disintegrating aspirin tablets. The amount of drug released using the new apparatus was significantly higher than the rotating basket but significantly lower than the rotating paddle at each of the stirring speeds studied. The results obtained using this new apparatus were highly reproducible compared to the USP/NF apparatus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f285883125c2a7aba0fb79c0576fdfd https://doi.org/10.3109/03639049409038391 Zobrazit plný text záznamu