Metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into aromatic amides with molecular iodine in aq ammonia, and hydrogen peroxide

Autor:	Hideo Togo, Ryosuke Ohmura, Misato Takahata
Rok vydání:	2010
Předmět:	inorganic chemicals Primary (chemistry) Chemistry Organic Chemistry Halide chemistry.chemical_element Oxidative phosphorylation Iodine Biochemistry chemistry.chemical_compound Ammonia Metal free Drug Discovery Organic chemistry Hydrogen peroxide
Zdroj:	Tetrahedron Letters. 51:4378-4381
ISSN:	0040-4039
Popis:	Various primary alcohols, particularly benzylic alcohols, could be converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq. NH3, followed by reaction with ∼30% aq H2O2. Similarly, various benzylic halides could be also converted into the corresponding aromatic amides in good yields in a one-pot manner by treatment with molecular iodine in aq NH3, followed by reaction with ∼30% aq H2O2. The present reactions involve the metal-free one-pot oxidative conversion of benzylic alcohols and benzylic halides into the corresponding aromatic amides, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7f285280b107d5c31b6316794faa4b9f https://doi.org/10.1016/j.tetlet.2010.06.051 Zobrazit plný text záznamu Full Text from ScienceDirect