Bone marrow immunoregulatory peptides (myelopeptides): Isolation, structure, and functional activity

Autor:	R. V. Petrov, A. A. Mikhailova, L. A. Fonina
Rok vydání:	1997
Předmět:	Chemistry Cellular differentiation Organic Chemistry Biophysics General Medicine Biochemistry High-performance liquid chromatography Myelopeptides Homology (biology) Biomaterials medicine.anatomical_structure In vivo medicine Bone marrow Hemoglobin Solid phase extraction
Zdroj:	Biopolymers. 43:139-146
ISSN:	0006-3525
DOI:	10.1002/(sici)1097-0282(1997)43:2<139::aid-bip7>3.0.co;2-w
Popis:	Myelopeptides (MPs) are bioregulatory mediators of bone marrow origin. Several individual MPs have been isolated from the supernatant of porcine bone marrow cell culture by successive solid phase extraction and reversed-phase high performance liquid chromatography. Two of them, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), were synthesized and their biological activities were comprehensively studied. Both hexapeptides display pronounced immunoregulatory activity but their final effects as well as mechanisms of action are different. Peptides MP-1 and MP-2 are identical to conservative fragments 33-38 alpha- and 31-36 beta-chains of hemoglobin, respectively. The sequences of other isolated MPs have no homology with any functional protein. The role of MPs in bioregulatory processes in vivo is discussed.
Databáze:	OpenAIRE
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