Clinical and histological features of autoantibody-negative autoimmune hepatitis in Chinese patients: A single center experience
| Autor: | Hai Li, Lei Shen, Jing Hua, Xiong Ma, Shan Shan Huang, Shen Li, Wei Jun Jiang, De Kai Qiu, Qi Xia Wang, Xiao Xiao, Haiyan Zhang, Qi Miao |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Hepatitis
medicine.medical_specialty Pathology biology Anti-nuclear antibody business.industry Gastroenterology Autoantibody Retrospective cohort study Autoimmune hepatitis medicine.disease Single Center digestive system diseases immune system diseases Internal medicine medicine biology.protein Antibody Young adult business |
| Zdroj: | Journal of Digestive Diseases. 14:175-180 |
| ISSN: | 1751-2972 |
| DOI: | 10.1111/1751-2980.12022 |
| Popis: | Objective This study aimed to define the clinical features of Chinese patients with autoantibody-negative autoimmune hepatitis (AIH) and to refine the diagnosis and management of these atypical patients in a single Chinese center. Methods A retrospective evaluation of 167 Chinese patients with AIH was performed. Patients meeting comprehensive criteria with the absence of antinuclear antibodies, smooth muscle antibodies, liver-kidney microsomal-1 antibodies and antimitochondrial antibodies were defined as autoantibody-negative patients. Results In total, 17 (10.2%) of the 167 patients with AIH were autoantibody-negative. The general status and biochemical tests between the classical and autoantibody-negative patients were not significantly different (P > 0.05). Serum immunoglobulin G levels of the autoantibody-negative AIH patients were lower than those of the classical AIH ones (P = 0.004). There was no significant difference in the histological inflammatory grades between the two groups; however, advanced histological stages were more common in the autoantibody-negative AIH group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |