Neuronal Activity of Pallidal Versus Cerebellar Receiving Thalamus in Patients with Cervical Dystonia
| Autor: | H.A. Jinnah, Alexey Sedov, R. S. Medvednik, Aasef G. Shaikh, Ulia Semenova, Valentin Popov |
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| Rok vydání: | 2020 |
| Předmět: |
Dystonia
Cerebellum medicine.medical_specialty Neurology business.industry 05 social sciences Thalamus medicine.disease 050105 experimental psychology Midbrain 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure nervous system Basal ganglia medicine Premovement neuronal activity 0501 psychology and cognitive sciences Neurology (clinical) Cervical dystonia business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The Cerebellum. 20:151-159 |
| ISSN: | 1473-4230 1473-4222 |
| DOI: | 10.1007/s12311-020-01194-8 |
| Popis: | Cervical dystonia (CD) is a movement disorder characterized by a stereotyped pattern of involuntary turning or tilting of the head, often combined with jerky or tremulous movements. Hypotheses for the origin of CD have traditionally focused on the basal ganglia, but the contemporary discussion has considered the potential role of altered cerebellar function. As basal ganglia and the cerebellum largely project to the different thalamic nuclei, alterations in pallidal versus cerebellar output could be reflected in the activity of these thalamic regions. In this study, we analyzed a unique historic database where the single-unit activity of pallidal and cerebellar receiving thalamic nuclei was measured en route to the mesencephalon. We compared the single-unit activity of pallidal and cerebellar receiving thalamic neurons in three groups of CD patients manifesting as pure dystonia, pure jerky head oscillations, and dystonia plus jerky head oscillations. We found that among different CD manifestations, the characteristics of neuronal firing, such as burst versus a single-spike pattern, vary in cerebellar thalamic receiving nuclei. The cerebellar receiving region in patients with jerky oscillations had single-spikes neurons primarily. Wherein the manifestation of CD did not influence pattern distribution in the pallidal receiving thalamic area. We also found increased neuronal firing rate correlated with strength of theta-band neuronal oscillations during muscle contractions associated with dystonia. These results demonstrate that the manifestations of CD, such as pure dystonia, pure jerky head oscillations, or dystonia and jerky head oscillations, determine the thalamic neuronal properties. |
| Databáze: | OpenAIRE |
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