Effect of a new antitumor drug cycloplatam on DNA structure and production
| Autor: | A. G. Tikhomirov, L. B. Gorbacheva, I. S. Sokolova, L. Yu. Dederer |
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| Rok vydání: | 1998 |
| Předmět: |
Cycloplatam
Drug Cisplatin media_common.quotation_subject General Medicine Biology Molecular biology General Biochemistry Genetics and Molecular Biology In vitro chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Amine gas treating Bone marrow Incubation DNA media_common medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 125:172-174 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf02496851 |
| Popis: | The new antitumor drug cycloplatam [amine (cyclopentylamine)-S-(-)-malatoplatinum(II)] caused dose-dependent formation of interstrand DNA ligationsin vitro depending on the duration of incubation. Like cisplatin, cycloplatam caused a deep and long inhibition of DNA production in tumor cells. The effect of cycloplatam in bone marrow and small intestine epithelium cells was weaker and shorter than that of cisplatin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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