| Popis: |
Recent advances in interferon and interleukin research entailed great interest upon specific and sensitive assays in biological media. Concurrently with the availability of (monoclonal) antibodies, a development in immunological assays originated, providing increased specificity over the conventional biological assays. However, most immunological assays, notwithstanding their sensitivity, cannot distinguish between biologically active and inactive interferons or interleukins. This drawback resulted in new assays, based on the use of receptors, which combine the advantages of both biological and immunological assays. In addition, quantitative chemical analysis of interferons and interleukins employing chromatographic, electrophoretic, mass spectrometric and surface plasmon resonance-based techniques, has emerged recently and appears to possess potentials for rapidly and specificity. So far, chemical assays lack the sensitivity for the determination of interferons and interleukins in biological matrices. |
