| Autor: |
BS Henry Preston, Anthony J. Bourne, Lynette Moore, BS Roger Byard, BS David Moore |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Pediatric Pathology & Laboratory Medicine. 17:601-610 |
| ISSN: |
1077-1042 |
| DOI: |
10.1080/15513819709168737 |
| Popis: |
Hepatocellular carcinoma is an uncommon malignancy in young children associated with a variety of congenital and acquired conditions. It has been generally held that idiopathic neonatal hepatitis is not an antecedent of hepatocellular neoplasia in childhood. We report a 28-month-old girl in whom a diagnosis of neonatal giant cell hepatitis was confirmed by liver biopsy at 4 months of age who was followed up with serial liver biopsies. Hepatitis B and C virus infection and metabolic abnormalities had been excluded by appropriate testing. There was no history of parenteral nutrition. The morphologic criteria for a diagnosis of cirrhosis were satisfied in a liver biopsy undertaken at 23 months of age. At 28 months a laparotomy was performed because of continuing jaundice and the development of an abdominal mass. Biopsy of the mass revealed a hepatocellular carcinoma. Ploidy studies showed an aneuploid tumor and a hyperdiploid karyotype was confirmed by chromosomal analysis. This case demonstrates by sequential biopsy the progression from neonatal hepatitis to cirrhosis and hepatocellular carcinoma in a young child. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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