Molecular Mechanism of the Nucleosome Assembly/Disassembly Mediated by Histone Chaperone CIA; Implications for Epigenetic Information Inheritance

Autor:	Yusuke Akai, Toshiya Senda, Masamitsu Eitoku, Masami Horikoshi, Norihiko Sano, Ryo Natsume
Rok vydání:	2008
Předmět:	musculoskeletal diseases Genetics Nucleosome assembly Histone H1 Histone H2A Histone methylation Chromatosome Nucleosome Histone code macromolecular substances Histone octamer Biology Cell biology
Zdroj:	Seibutsu Butsuri. 48:108-113
ISSN:	1347-4219 0582-4052
DOI:	10.2142/biophys.48.108
Popis:	CIA is the most conserved histone chaperone in the eukaryotes. The biochemical and X-ray crystallographic studies have revealed that CIA splits the histone (H3-H4)2 tetramer into two histone H3-H4 dimers through the CIA-histone-H3-H4 complex formation. The histone (H3-H4)2 tetramer splitting activity of CIA gives new insights into the mechanism of the nucleosome assembly/disassembly, the relationship between nucleosome assembly/disassembly and epigenetic modifications of histones, and the mechanism of the epigenetic information inheritance through the semi-conservative nucleosome replication mode.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ee1c23dc10f7cb5d1f6f39977745f1b https://doi.org/10.2142/biophys.48.108 Zobrazit plný text záznamu