ChemInform Abstract: 1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine: A New Selective Fluorinating Agent

Autor:	Wonpyo Hong, W. Chris Petersen, Viacheslav A. Petrov, Steve Swearingen
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Yield (chemistry) Reagent Halogenation Tetrafluoroethylene General Medicine Dimethylamine Tertiary alcohols Medicinal chemistry Alkyl
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200134290
Popis:	The title compound has been prepared in 96–98% yield by the reaction of tetrafluoroethylene and dimethylamine. 1,1,2,2-Tetrafluoroethyl- N , N -dimethylamine ( 1 ) is found to be an effective reagent for the conversion of alcohols into alkyl fluorides. Reaction of 1 and primary alcohols proceeds with high yield formation of the corresponding alkyl fluorides at elevated temperature. However, the reaction of secondary and tertiary alcohols rapidly takes place at 0–10°C, producing corresponding alkyl fluorides as major product along with some olefins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7ed4d8fe4dad03e41e93a8567803d5f7 https://doi.org/10.1002/chin.200134290 Zobrazit plný text záznamu Plný text