Effect of clofelin on neuronal spike activity in the midbrain and posterior horn of the spinal cord

Autor: B. T. Moroz, Z. A. Sakvarelidze, A. A. Zaitsev, S. M. Butkhuzi, V. V. Kolchin
Rok vydání: 1989
Předmět:
Zdroj: Bulletin of Experimental Biology and Medicine. 108:1144-1147
ISSN: 1573-8221
0007-4888
DOI: 10.1007/bf00840660
Popis: The pain relieving action of clofelin and of other central adrenopositive drugs has been clearly demonstrated in recent years, and on that basis the concept of the adrenergic regulation of pain has been formulated [3-5,7,12,14]. Meanwhile some of its most important postulates require further detailed examination. Whereas the neuroehemical and receptor aspects of adrenergic analgesia can be considered to be sufficiently well elaborated, the neurophysiological mechanisms of the analgesic effect of clofelin-like compounds have received much less study. Analysis of the action of adrenopositive drugs on the homeostatic regulation of nociception, and the discovery of the neuronal mechanisms of their effect and of their specificity in relation to influences of a nocieeptive nature are particularly important. The effect of clofelin was accordingly studied on nociceptive responses of neurons of the midbrain -a structural component of the endogenous painrelieving systems of the body, and of neurons of the spinal cord -the afferent input system controlling the spread of impulsation to effector cells and to structures at a higher level of the CNS.
Databáze: OpenAIRE
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