Enhanced hepatocarcinogenesis in acatalasemic mice treated with diethylnitrosamine
| Autor: | Kazuhisa Taketa, Yuka Funamori, Masaki Sato, Satoru Ikeda, Da Hong Wang, Shohei Kira |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pathology Hepatology biology business.industry Ratón medicine.medical_treatment Intraperitoneal injection Male mice medicine.disease_cause Tumor tissue Infectious Diseases Endocrinology Catalase Internal medicine biology.protein Medicine business Carcinogenesis Carcinogen Histological examination |
| Zdroj: | Hepatology Research. 12:217-224 |
| ISSN: | 1386-6346 |
| DOI: | 10.1016/s1386-6346(98)00065-5 |
| Popis: | Diethylnitrosamine (DEN)-induced hepatocellular carcinogenesis was compared between C3H/AnLCsbCsb (acatalasemic) and C3H/AnLCsaCsa (normal) mice. A total of 31 normal and 38 acatalasemic male mice, average age 9 weeks, received a single intraperitoneal injection of DEN (75 mg/kg body wt) weekly for 6 weeks. All animals that survived until the end of week 31 (25th week after the last injection of DEN) were sacrificed and the development of liver tumors was found. They grossly varied from one to multiple in number and from 1 to 15 mm in diameter in both groups. The numbers and size of liver tumors per liver were significantly greater (P |
| Databáze: | OpenAIRE |
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