Tandem synthesis of aromatic amides from styrenes in water
| Autor: | Aniket A. Parab, Aniket S. Karpe, Kamlesh S. Vadagaonkar, Pratima A. Sathe, Babasao S. Parade, Atul C. Chaskar |
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| Rok vydání: | 2018 |
| Předmět: |
Aqueous solution
Tandem 010405 organic chemistry Organic Chemistry chemistry.chemical_element Compatibility (geochemistry) 010402 general chemistry Iodine 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Ammonia chemistry Amide Drug Discovery Functional group Nucleophilic substitution Organic chemistry |
| Zdroj: | Tetrahedron Letters. 59:2820-2823 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2018.06.021 |
| Popis: | An expedient one-pot synthesis of aromatic amides has been reported from styrenes in the presence of N-bromosuccinimide and iodine by using aqueous ammonia in water. The reaction proceeds through the formation of α-bromoketone as an intermediate in the presence of NBS and water. α-Bromoketone on reaction with iodine forms bromodiiodoketone which on nucleophilic substitution with aqueous ammonia gives aromatic amide. Substituted aromatic amides were obtained in good yields with wide functional group compatibility. |
| Databáze: | OpenAIRE |
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