| Popis: |
Background Little is known about the effects of direct oral anticoagulants (DOACs) in cancer[1]related venous thromboembolism patients. Methods Data of patients with cancer-related venous thromboembolism (VTE) were retrieved from King Abdulaziz Medical City Database during 2016–2020. We excluded patients who were not using oral anticoagulants, used anticoagulants for 0.05); 48.24% of patients in the DOAC group and 46.98% of patients in the warfaringroup were men (p > 0.05). The mean HAS-BLED score was 3.7 ± 3.8 in the NOAC group and 3.8 ± 3.9 in the warfaringroup (p > 0.05). Furthermore, among patients with cancer-related VTE, DOAC was associated with no difference in major bleeding or recurrence events (CRR = 0.91, 95% CI = 0.78–1.05; CRR = 0.63, 95% CI = 0.52–0.77, respectively), and significantly reduced death from any cause (aHR = 0.65, 95% CI = 0.52–0.80) compared with warfarin. Conclusions In elderly patients with cancer-related VTE, DOAC was associated with reduced death from any cause compared with warfarin, whereas no difference in major bleeding or recurrent VTE were observed between these treatment modalities. |
