| Autor: |
Péter Keglevich, András Keglevich, Áron Szigetvári, Miklós Dékány, Erzsébet Mernyák, János Wölfling, László Hazai, Szantay Csaba, Vivian Zsiros |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Current Organic Chemistry. 23:959-967 |
| ISSN: |
1385-2728 |
| DOI: |
10.2174/1385272823666190614113218 |
| Popis: |
10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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