A Robust, Streamlined Approach to Bosutinib Monohydrate

Autor:	Gregory J. Withbroe, Chris Seadeek, Rajappa Vaidyanathan, Brian C. Vanderplas, Kevin P. Girard, Steven M. Guinness
Rok vydání:	2012
Předmět:	Crystallography Materials science business.industry Organic Chemistry Bosutinib Monohydrate Recrystallization (metallurgy) Physical and Theoretical Chemistry Process engineering business
Zdroj:	Organic Process Research & Development. 17:500-504
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op300087r
Popis:	This article describes a systematic approach used to streamline the process for the isolation of bosutinib monohydrate, a promiscuous solvate former. A thorough understanding of the complex solid form landscape was garnered, and this knowledge was used to develop a process that routinely delivered the correct solid form and excellent purity at the end of the last bond-formation step, without the need for additional recrystallization and/or solid form conversion steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7eb02567bcf10cd24f2de6af0d80d8f4 https://doi.org/10.1021/op300087r Zobrazit plný text záznamu