| Autor: |
Max Kam-Kwan Chan, Emily Lok-Yiu Chan, Zoey Zeyuan Ji, Alex Siu-Wing Chan, Chunjie Li, Kam-Tong Leung, Ka-Fai To, Patrick Ming-Kuen Tang |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Exploration of Targeted Anti-tumor Therapy. :316-343 |
| ISSN: |
2692-3114 |
| DOI: |
10.37349/etat.2023.00137 |
| Popis: |
Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
