Brain stroke in patients with Covid-19 disease

Autor: Rebecca Maltri, Fernanda Peronti Marino, Jorge Ygor Gonçalves dos Santos, Nathalia Polliana Rodrigues Melgaço, Vitória Aparecida Cunha, Paola Falcão Moreira Nogueira, Rafaela Charles Correia, Tiago Silva Carvalho
Rok vydání: 2021
Zdroj: São Paulo Medical Journal.
DOI: 10.5327/1516-3180.625
Popis: Background: Currently, the world is facing a pandemic caused by the SARSCoV-2, which has already infected millions of people and has accumulated countless deaths. Association has been reported between severe conditions of this disease and the occurrence of neurological manifestations, including stroke. The mechanisms that trigger this cerebrovascular disease in infected people are not defined yet, but it’s believed that they involve inflammatory reaction, vascular endothelial dysfunction and hypercoagulopathy present in SARS-CoV-2 infection. Objectives: Verify the studies which relate the cerebrovascular disorders caused by the infection of SARS-CoV-2, in order to elucidate its performance and determine the patient’s management as a way to avoid outcomes such as stroke and other neurological conditions losses. Methods: The subject is approached through a narrative review of the literature without meta-analysis. A bibliographic survey was made out, from December 2019 to June 2020, in digital databases. Results: The relation between ischemic and hemorrhagic strokes with coronavirus infection shows a possible mechanism of action of the virus related to ACE2, damaging tissues, including the brain. In addition, a huge relation has been identified between coagulopathy induced by the infectious condition and the occurrence of stroke, since the intense inflammatory storm produced raises the risks of occurrence of cerebrovascular events. Conclusions: The activity of this coronavirus against ACE2 has been shown to increase the secretion of pro-inflammatory substances, causing brain damage. Although this is a new disease, it’s possible to establish the stroke as a complication of COVID-19. It should be considered, especially in critically ill patients, and promptly assisted.
Databáze: OpenAIRE