Differential Effects of the Perinatal Steroid Environment on Three Sexually Dimorphic Parameters of the Rat Brain1
| Autor: | Roger A. Gorski, Robert J. Handa, Judith N. Schoonmaker, Philippe Corbier, James E. Shryne |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class medicine.medical_treatment Cell Biology General Medicine Biology Androgen Preoptic area chemistry.chemical_compound Steroid hormone Endocrinology Reproductive Medicine chemistry Internal medicine Estradiol benzoate medicine Gonadotropin Luteinizing hormone Testosterone Sexually dimorphic nucleus |
| Zdroj: | Biology of Reproduction. 32:855-864 |
| ISSN: | 1529-7268 0006-3363 |
| DOI: | 10.1095/biolreprod32.4.855 |
| Popis: | Gonadectomy of male rats was performed at 0, 6-7 (6 h), 12-13 (12 h), or 24 h postnatably in order to examine the influence of testosterone exposure on sexual differentiation of the brain. The indices examined were: the volume of the sexually dimorphic nucleus of the preoptic area (SDNPOA) and luteinizing hormone (LH) and follicle-stimulating hormone (FSH) titers following estradiol benzoate (EB) and progesterone (P) administration. Control animals were sham-operated at 0 h and gonadectomized at 29 days of age (sham). A decrease in the percentage of males with elevated plasma LH levels following P was found with increasing delay before gonadectomy. Significant (P |
| Databáze: | OpenAIRE |
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