Time-dependent inactivation of steroid C17(20) lyase by 17β-cyclopropyl ether-substituted steroids
| Autor: | Angela L. Marquart, Marie E. Laughlin, Norton P. Peet, Cynthia A. Gates, Thomas R. Blohm, Philip M. Weintraub, Michael R. Angelastro |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
chemistry.chemical_classification
C17 20 lyase Stereochemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Heteroatom Pharmaceutical Science Ether Lyase Biochemistry Steroid chemistry.chemical_compound Enzyme chemistry Drug Discovery medicine Molecular Medicine Androstenes Molecular Biology Linker |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:97-100 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/0960-894x(95)00566-c |
| Popis: | Androstenes bearing a cyclopropyl group attached to the C-17β position with a heteroatom linker, designed as mechanism-based inhibitors of steroid C 17(20) lyase, were found to be potent, time-dependent inhibitors of this enzyme. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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