The CD6 Scavenger Receptor Is Differentially Expressed on a CD56dim Natural Killer Cell Subpopulation and Contributes to Natural Killer-Derived Cytokine and Chemokine Secretion
| Autor: | Bernadette Müller, Ludmila Umansky, Monika Braun, Dominik ter Meer, Joachim W. Ellwart, Barbara Mosetter, Silke Raffegerst, Stefani Spranger, Susanne Wilde, Barbara Simm, Dolores J. Schendel, Christine S. Falk, Tina Lerchl |
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| Rok vydání: | 2010 |
| Předmět: |
Chemokine
Lymphokine-activated killer cell ZAP70 Degranulation hemic and immune systems chemical and pharmacologic phenomena Biology Natural killer T cell Natural killer cell Cell biology medicine.anatomical_structure Immunology Chemokine secretion medicine biology.protein Immunology and Allergy CXCL10 |
| Zdroj: | Journal of Innate Immunity. 3:420-434 |
| ISSN: | 1662-8128 1662-811X |
| Popis: | The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration. Here, we demonstrate that CD6 is differentially expressed by a subpopulation of peripheral CD56dim natu- ral killer (NK) cells and absent on CD56bright NK cells. CD56dimCD16+ cells represent the major NK subset in the periphery, and most cells within this group are positive for CD6. Most killer immunoglobulin-like receptor- and immunoglobulin-like transcript-positive cells also belong to the CD6+ subpopulation, as expected from their restricted expression on CD56dim NK cells. In addition, CD6+ NK cells are similar to the newly identified CD94lowCD56dim NK subpopulation and most distant from the recently defined CD27+ NK subpopulation based on the reverse correlation of expression between CD6 and CD27, a marker associated primarily with CD56bright NK cells. With respect to CD6 function on NK cells, direct CD6 triggering did not result in degranulation but induced secretion of cytokines (interferon-γ and tumor necrosis factor-α) and chemokines [CXCL10 (IP-10), CXCL1 (GRO-α)]. Thus, CD6 expression on peripheral NK cells marks a novel CD56dim subpopulation associated with distinct patterns of cytokine and chemokine secretion. |
| Databáze: | OpenAIRE |
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