Enantioselective rhodium-catalyzed addition of arylboronic acids to N-heteroaryl ketones: synthesis of α-hydroxy acids
| Autor: | Jinbin Zhu, Zhenyue Li, Jiaqi Li, Duanshuai Tian, Ronghua Xu, Zhiyong Tan, Zhengwang Chen, Wenjun Tang |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Chemical Science. 14:1606-1612 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/d2sc05907j |
| Popis: | Efficient asymmetric addition of aryl/heteroarylboronic acids to N-heteroaryl ketones is established by employing the Rh-WingPhos catalyst, affording a variety of chiral α-heteroaryl alcohols. The method provides a practical access to chiral tertiary α-hydroxyl acids. |
| Databáze: | OpenAIRE |
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