Reactions of octahydroacridine-4-carbonitrile (carboxamide) with electrophilic reagents

Autor:	Aleksandr V. Mazepa, Ekaterina V. Zaliznaya, Elena V. Vashchenko, Oleg K. Farat, Viktor I. Markov, Nikolay Yu. Gorobets, Roman I. Zubatyuk
Rok vydání:	2015
Předmět:	Substitution reaction Chemistry medicine.drug_class Japp–Klingemann reaction Organic Chemistry chemistry.chemical_element Carboxamide Azo coupling Nitrogen Electrophilic substitution Reagent Electrophile medicine Organic chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 51:327-333
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-015-1703-8
Popis:	Octahydroacridine-4-carbonitrile (carboxamide) was shown to react with aryldiazonium salts and other electrophilic reagents in acidic and neutral media. The reactions occurred at the methine carbon atom, forming the corresponding 4-functionalized derivatives. The obtained azo compounds decomposed at 140–155°С with elimination of nitrogen and gave products formed by the reactions of radical intermediates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e92cfec6c11fcac89acbe76e11a1da7 https://doi.org/10.1007/s10593-015-1703-8 Zobrazit plný text záznamu Plný text ve formátu PDF