Support studies for the conversion of actinobolin into bactobolin

Autor:	Russell L. Underwood, Bert Fraser-Reid
Rok vydání:	1990
Předmět:	Bactobolin Stereochemistry Chemistry Actinobolin
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :731
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19900000731
Popis:	Strategies for the final steps in a synthesis of bactobolin have been examined on substrates obtained by retrograde transformations of actinobilin. It is shown that α-acetamido ketones react with LiCHCl2 from the Re face thereby generating the C-5 configuration required for bactobolin. However, the transformations involved are highly substrate specific. The reasons for this sensitivity are not apparent, but they indicate the need for caution in laying plans for the finals steps of a synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e8e5bd2bd83923acee3d90489781112 https://doi.org/10.1039/p19900000731 Zobrazit plný text záznamu