Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies
| Autor: | Zheng Jian Li, Nripen Singh, Yi Li, Srinivas Chollangi, Michael C. Borys, Ray Parker |
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| Rok vydání: | 2015 |
| Předmět: |
Chromatography
biology Chemistry Precipitation (chemistry) Elution medicine.drug_class High-throughput screening Bioengineering Monoclonal antibody Applied Microbiology and Biotechnology Neutralization law.invention law biology.protein Recombinant DNA medicine Protein A Chromatography column Biotechnology |
| Zdroj: | Biotechnology and Bioengineering. 112:2292-2304 |
| ISSN: | 0006-3592 |
| DOI: | 10.1002/bit.25639 |
| Popis: | To be administered to patients, therapeutic monoclonal antibodies must have very high purity, with process related impurities like host-cell proteins (HCPs) and DNA reduced to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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