Estimating of Origin and Evolutionary History of Human Immunodeficiency Virus Type 2 in Cuba
| Autor: | Enrique Noa, Liuber Y. Machado, Marta Dubed, Dayamí Martín, Dervel F Díaz, Héctor M. Díaz, Madeline Blanco, Orlando Martínez, María L Sánchez |
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| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Immunology and Infectious Diseases. 4:20-25 |
| ISSN: | 2333-3286 2333-2719 |
| DOI: | 10.13189/iid.2016.040202 |
| Popis: | Background: Infection with human HIV-2 is endemic in West Africa. The virus originated from West African sooty mangabeys during the first half of the 20th century and an epidemic initiation in Guinea Bissau that coincides with the independence war (1963-1974). The HIV-2 group A is categorized as epidemic group. The presence of HIV-2 group A in Cuba has been previously documented. However, the evolutionary history of HIV-2 group A in the Cuban epidemic is unknown. The aim of this work is to estimate the origin and evolutionary history of the HIV-2 group A in Cuba. Methods: We used a Bayesian coalescent method to analyze the env gene of Cuban HIV-2 group A. The rate of nucleotide substitution was determined and was used to date the phylogenies and reveal the evolutionary history of HIV-2 group A in Cuba. Results: Multiple introductions of HIV-2 group A, mainly from Guinea Bissau and Portugal were detected. The most recent common ancestor of Cuban HIV-2 groups A was dated back to about 1972 (95 % HPD: 1966-1978). The rate of nucleotide substitutions was 5.02 x 10-3 substitutions per site per years (95 % HDP: 4.51-5.52 x 10-3). Conclusions: The results of this study allowed for the first time to estimate the evolutionary history of HIV-2 in Cuba and establish the basis for phylogeographic and phylodynamics studies. |
| Databáze: | OpenAIRE |
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