Synthesis and structure-activity relationships of novel THF 1β-methylcarbapenems

Autor:	William J. Weiss, Subas M. Sakya, Nilda V. Jacobus, Francis P. Tally, Karen Bush, Panayota Bitha, Lin Yang I, Stanley A. Lang, Strohmeyer Timothy W, Peter Petersen, Niraja Bhachech, Youjun Yang, Li Zhong, Testa Raymond T, Ving J. Lee
Rok vydání:	1997
Předmět:	Imipenem Chemistry Stereochemistry Pseudomonas aeruginosa Organic Chemistry Clinical Biochemistry Pharmaceutical Science biochemical phenomena metabolism and nutrition bacterial infections and mycoses Antimicrobial medicine.disease_cause Biochemistry Combinatorial chemistry Meropenem Chemical synthesis chemistry.chemical_compound Drug Discovery polycyclic compounds medicine Lactam Molecular Medicine Stereoselectivity Molecular Biology medicine.drug Antibacterial agent
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 7:1671-1676
ISSN:	0960-894X
Popis:	A series of twelve highly active aminomethyl-THF 1β-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e7cf0fda2095464b1f1974109e04d23 https://doi.org/10.1016/s0960-894x(97)00282-5 Zobrazit plný text záznamu Full Text from ScienceDirect