Protective Effect of Ifenprodil against Glucose Deprivation-Induced Damage in Cultured Rat Hippocampal Neurons
| Autor: | Shuji Takaori, Tadahiro Shikimi, Keisuke Hattori |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
chemistry.chemical_classification medicine.medical_specialty Central nervous system Hippocampus Biology Trypsin Endocrinology medicine.anatomical_structure Enzyme stomatognathic system Biochemistry chemistry Hypothalamus Cerebral cortex Internal medicine medicine biology.protein Peptide sequence Glyceraldehyde 3-phosphate dehydrogenase medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 73:97-100 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.60.97 |
| Popis: | A human urinary trypsin inhibitor, urinastatin (UT)-like immunoreactive substance with trypsin inhibitory activity, was demonstrated in certain brain regions in rats, especially the cerebral cortex, hippocampus and hypothalamus. Although this UT-like substance in the rat brain displayed an N-terminal amino acid sequence similar to that of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), it did not show any GAPDH activity. These results indicate that the UT-like substance in the rat brain is a protein different from GAPDH and indicates a localized distribution within certain brain regions partly related to learning and memory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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