Effect of Low-Dose Aspirin on Platelet Angiotensin II Binding and on the Pressor Response To

Autor:	Infused Angiotensin, M. M. Ramsay, Philip N. Baker, Fiona Broughton Pipkin
Rok vydání:	1996
Předmět:	medicine.medical_specialty Aspirin business.industry Obstetrics and Gynecology Platelet membrane glycoprotein Angiotensin II Endocrinology Blood pressure Pressor response Internal medicine Internal Medicine Medicine Platelet business Receptor Low dose aspirin medicine.drug
Zdroj:	Hypertension in Pregnancy. 15:241-249
ISSN:	1525-6065 1064-1955
Popis:	Objective: To determine the effect of low-dose aspirin (75 mg o.d.) on platelet angiotensin II (AH) binding and on AH pressor sensitivity, and to study both the mechanism of the aspirin-induced reduction in AH pressor sensitivity and the potential use of platelet All binding in assessing the response to low-dose aspirin therapy.Methods: Parallel studies of the effects of low-dose aspirin on platelet All binding and All pressor sensitivity were performed on 10 nonpregnant subjects. All infusions and platelet All binding estimations were performed prior to aspirin ingestion, 1 h after aspirin ingestion and after 1 month of oral aspirin ingestion.Results: Platelet All binding was diminished 1 h after aspirin ingestion as compared to the initial values (P = 0.01). An increased AH infusion rate was required to produce a 10 mm Hg rise in systolic blood pressure (P < 0.05), and there was a decrease in the slope of the curve of systolic pressor responses to All (P = 0.01). After 1 month of aspirin, although the i...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e71afc5008341f51faacfbc1dfe16f1 https://doi.org/10.3109/10641959609015707 Zobrazit plný text záznamu