| Popis: |
Myelodysplastic syndrome (MDS) with myelofibrosis having intraoral manifestations as ecchymosis, unprompted gingival bleeding, and generalized gingival overgrowth with associated periodontal disease is one of the rare cases. MDS is a clonal disorder of pluripotent hematopoietic stem cells. Myelofibrosis is a disorder where normal bone marrow is replaced with a fibrous scar tissue. It is a complication of MDS. Here, we are discussing a rare case report of MDS with myelofibrosis manifesting as intraoral ecchymosis. MDS with myelofibrosis is aggressive disorder of elderly whose pathophysiology remains unknown with a poor prognosis. When myelofibrosis is observed in a bone marrow specimen, further investigation of the patient with respect to splenomegaly, leukocyte count, peripheral blood smear and bone marrow findings, and karyotype will serve as a guide to correct diagnosis. |
