Hepatotoxic Effects of 1-Furan-2-yl-3-pyridin-2-yl-propenone, a New Anti-Inflammatory Agent, in Mice
| Autor: | Chun Hwa Kim, Tae Won Jeon, Sil Shin, Sangkyu Lee, Tae Cheon Jeong, Mi Jeong Kang, Sang-Hyun Kim, Wonku Kang, Jae Ho Choi, Eung-Seok Lee |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Reactive oxygen species biology medicine.drug_class Biochemistry Anti-inflammatory Nitric oxide Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Enzyme chemistry In vivo Drug Discovery medicine biology.protein Molecular Medicine Adverse effect |
| Zdroj: | Biomolecules and Therapeutics. 17:318-324 |
| ISSN: | 1976-9148 |
| Popis: | － 1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide. In the present study, adverse effects of FPP-3 on hepatic functions were determined in female BALB/c mice. When mice were administered with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days orally, FPP-3 significantly increased absolute and relative weights of liver with a dose-dependent manner. In addition, FPP-3 administration dramatically increased the hepatotoxicity parameters in serum at 500 mg/kg, in association of hepatic necrosis. FPP-3 significantly induced several phase I enzyme activities. To elucidate the possible mechanism(s) involved in FPP-3 induced hepatotoxicity, we investigated the hepatic activities of free radical generating and scavenging enzymes and the level of hepatic lipid peroxidation. FPP-3 treatment significantly elevated the hepatic lipid peroxidation, measured as the thiobarbituric acid-reactive substance, and the activity of superoxide dismutase. Taken together, the present data indicated that reactive oxygen species might be involved in FPP-3-induced hepatotoxicity.Keywords: FPP-3, Hepatotoxicity, Lipid peroxidation |
| Databáze: | OpenAIRE |
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