Autor:	Ieva Drulyte, Aspen Rene Gutgsell, Pilar Lloris-Garcerá, Michael Liss, Stefan Geschwindner, Mazdak Radjainia, Jens Frauenfeld, Robin Löving
Rok vydání:	2022
DOI:	10.1101/2022.07.05.498330
Popis:	Membrane proteins are the largest group of therapeutic targets in a variety of disease areas and yet, they remain particularly difficult to investigate. We have developed a novel one-step approach for the incorporation of membrane proteins directly from cells into lipid Salipro nanoparticles. Here, with the pannexin1 channel as a case study, we demonstrate the applicability of this method for structurefunction analysis using SPR and cryo-EM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e4e5069317b7b8e7b53f54204703224 https://doi.org/10.1101/2022.07.05.498330 Zobrazit plný text záznamu