Differential diagnosis of solitary pulmonary nodules using 99mTc-3P4-RGD2 scintigraphy
| Autor: | Tiefeng Ji, Qingjie Ma, Bing Jia, Bin Ji, Guoqing Zhao, Xueju Wang, Shi Gao, Zhenguo Han |
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| Rok vydání: | 2011 |
| Předmět: |
Tumor angiogenesis
Pathology medicine.medical_specialty Solitary pulmonary nodule biology medicine.diagnostic_test business.industry Integrin Early detection General Medicine medicine.disease Scintigraphy In vivo medicine biology.protein Radiology Nuclear Medicine and imaging Radiology Molecular imaging Differential diagnosis business |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 38:2145-2152 |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-011-1901-2 |
| Popis: | Purpose Targeting of integrin ανβ3 with molecular imaging agents offers great potential in early detection and monitoring of tumour angiogenesis. Recently, an RGD (Arg-Gly-Asp) tracer, 99mTc-3P4-RGD2, with high affinity to integrin ανβ3 and in vivo tumour uptake was developed. In this study, we evaluate the feasibility of this novel radiotracer in the noninvasive differentiation of solitary pulmonary nodules (SPNs). |
| Databáze: | OpenAIRE |
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