Use of low-dose rocuronium for intubation of children during volunteer surgery abroad1
| Autor: | Judith E. Brill, George D. Politis, John S. Jones |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry medicine.medical_treatment Laryngoscopy Placebo Surgery Anesthesiology and Pain Medicine El Niño Anesthesia Pediatrics Perinatology and Child Health medicine Breathing Intubation Halothane Rocuronium business Volunteer medicine.drug |
| Zdroj: | Pediatric Anesthesia. 15:648-652 |
| ISSN: | 1460-9592 1155-5645 |
| DOI: | 10.1111/j.1460-9592.2004.01519.x |
| Popis: | Summary Background : Low-dose rocuronium (ROC) might improve safety during volunteer surgery abroad (VSA) by facilitating intubation with a lower halothane concentration than is typically used. We hypothesized that 0.25 mg·kg−1 of ROC would improve intubation conditions during 3% halothane induction and still allow for rapid return to spontaneous ventilation (SV). Methods : During Operation Smile's 2002 mission to Honduras, patients aged 3 months–11 years were randomized to receive ROC 0.25 mg·kg−1 (n = 19), or placebo (n = 23). Induction was with 3% halothane in 100% O2, with ventilation assisted and controlled when possible, and normocarbia maintained. An i.v. was placed after induction, and ROC or placebo given. Direct laryngoscopy (DL) was performed 3 min later by a blinded laryngoscopist who assessed conditions according to predetermined criteria. Results : Adequate intubation conditions occurred in 89 and 87% of patients (P = 0.59), and mean times from DL until the return to SV were 9.8 and 4.3 min (P = 0.003), in the ROC and placebo groups, respectively. For the placebo group, the presence of SV at DL was predictive of inadequate intubation conditions (P = 0.006). Conclusions : When administering 3% halothane for induction of VSA patients, a high frequency of adequate intubation conditions can be achieved without a relaxant, rendering the known benefits of 0.25 mg·kg−1 of ROC unapparent. ROC 0.25 mg·kg−1 does allow rapid return to SV. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|