Stimulation of Mucociliary Activity by Substance P and Capsaicin is Not Mediated by Histamine

Autor:	Sven Lindberg, Ulf Mercke, Jan Dolata
Rok vydání:	1990
Předmět:	business.industry Substance P Stimulation Pharmacology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Otorhinolaryngology chemistry Capsaicin 030220 oncology & carcinogenesis Medicine 030223 otorhinolaryngology business Histamine
Zdroj:	American Journal of Rhinology. 4:141-144
ISSN:	1539-6290 1050-6586
DOI:	10.2500/105065890782018145
Popis:	The mucociliary activity in the rabbit maxillary sinus is stimulated by exogenous substance P and by histamine (via H1 receptors). Also, endogenous substance P released by capsaicin stimulates the mucociliary activity. A substance P-induced release of histamine has been reported. The possibility that the mucociliary stimulation by substance P is secondary to a release of histamine was investigated using a photoelectric technique. For both substance P (0.01, 0.1, and 1.0 μg/kg) and capsaicin (15 and 30 μg/kg), neither the maximum mucociliary response nor the time-course curve was affected by pretreatment with the H,-antagonist pyrilamine (4 mg/kg). It is concluded that the mucociliary effects produced by substance P and capsaicin are not secondary to a release of histamine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e372c99a6431d6874642320e2b29dd3 https://doi.org/10.2500/105065890782018145 Zobrazit plný text záznamu