Efficacy and safety of mitomycin-C in primary trabeculectomy

Autor: Joyce A. D’Antonio, Richard Lehrer, Garry P. Condon, Karen B Lauer, Rajiv Bindlish, James D Schlosser
Rok vydání: 2002
Předmět:
Zdroj: Ophthalmology. 109:1336-1341
ISSN: 0161-6420
DOI: 10.1016/s0161-6420(02)01069-2
Popis: Purpose To examine the 5-year complications and results of primary trabeculectomy with mitomycin-C (MMC). Design Retrospective, noncomparative interventional case series. Participants One hundred twenty-three eyes that underwent primary trabeculectomy with MMC between December 1991 and March 1995. Methods All patients received standard trabeculectomy performed by one of two surgeons, using a Weck cell-soaked pledget of MMC, 0.25, 0.33, or 0.5 mg/ml, for 0.5 to 5 minutes. Laser suture lysis was performed postoperatively for intraocular pressure control. Main outcome measures The incidence of complications, including hypotony with or without maculopathy, bleb leak or blebitis, pressure control, and medication reduction at yearly intervals. Results Mean preoperative and year 5 postoperative intraocular pressures (IOP) were 25.79 and 9.91 mmHg ( P t test). Hypotony (IOP P Conclusions Primary mitomycin trabeculectomy significantly lowers IOP at 5 years but is associated with a high incidence of delayed hypotony.
Databáze: OpenAIRE