ChemInform Abstract: Synthesis of 18-Demethyltaxoid via Stereoselective Allylation and Intramolecular Aldol Condensation Reactions

Autor:	Isamu Shiina, Teruaki Mukaiyama, Hayato Iwadare, Hiroki Sakoh, Hidehiro Arai
Rok vydání:	2010
Předmět:	Stereochemistry Chemistry Intramolecular force Stereoselectivity Aldol condensation General Medicine Optically active Ring (chemistry)
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200005196
Popis:	Optically active novel 18-demethyltaxiods were successfully synthesized from 2α,10β-dibenzyloxy-11β-(t-butyldimethylsiloxy)-7β-hydroxy-1α-(p-methoxybenzyloxy)-8β,15,15-trimethyl-4-methylene-trans-bicyclo[6.4.0]dodecan-9-one (2) which corresponds to the BC ring system of Taxol by stereoselective allylation and intramolecular aldol condensation reactions.
Databáze:	OpenAIRE
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