Synthesis of macrocyclic terpenoids by intramolecular carbonyl coupling: flexibilene and humulene

Autor:	Kenneth L. Kees, John E. McMurry, James R. Matz
Rok vydání:	1987
Předmět:	chemistry.chemical_classification Zirconium Humulene Chemistry Organic Chemistry chemistry.chemical_element Sesquiterpene Biochemistry Aldehyde Terpenoid chemistry.chemical_compound Intramolecular force Yield (chemistry) Reagent Drug Discovery Organic chemistry
Zdroj:	Tetrahedron. 43:5489-5498
ISSN:	0040-4020
Popis:	Total syntheses of two macrocyclic sesquiterpene hydrocarbons, humulene ( 1 ) and flexibilene ( 2 ) are discussed in detail. Both were prepared in high overall yield by titanium-induced cyclization of the appropriate keto aldehyde precursors ( 4 and 9 , respectively), themselves obtained by coupling of the vinylic zirconium reagent 22 with pi-allylpalladiums 26 and 23 .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e2525e5ab141ad44866a2821b5797cd https://doi.org/10.1016/s0040-4020(01)87732-2 Zobrazit plný text záznamu