Synthesis of macrocyclic terpenoids by intramolecular carbonyl coupling: flexibilene and humulene
Autor: | Kenneth L. Kees, John E. McMurry, James R. Matz |
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Rok vydání: | 1987 |
Předmět: | |
Zdroj: | Tetrahedron. 43:5489-5498 |
ISSN: | 0040-4020 |
Popis: | Total syntheses of two macrocyclic sesquiterpene hydrocarbons, humulene ( 1 ) and flexibilene ( 2 ) are discussed in detail. Both were prepared in high overall yield by titanium-induced cyclization of the appropriate keto aldehyde precursors ( 4 and 9 , respectively), themselves obtained by coupling of the vinylic zirconium reagent 22 with pi-allylpalladiums 26 and 23 . |
Databáze: | OpenAIRE |
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