| Autor: |
Weiguo Xu, Jingyun Wang, Bitao Zhu, Ying Zhang, Yanmin Zhou, Shujun Dong, Jianxun Ding, Hui Han, Ming Bi |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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