Selective anticonvulsant action of N-substituted imidazole-4,5-dicarboxylic acids against quinolinic acid
| Autor: | Ryzhov, Aleksandrova IIa, Lapin Ip, Piotrovskiĭ Lb |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry General Medicine Convulsants General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Tryptophan Metabolite Dicarboxylic acid chemistry Convulsant Imidazole Binding site Antagonism hormones hormone substitutes and hormone antagonists Quinolinic acid |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 106:989-992 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00834657 |
| Popis: | Selective antagonists of quinolinic acid (2,3-pyridine dicarboxylic acid, QUIN)--an endogenous convulsant tryptophan metabolite, administered intracerebroventricular to mice, were identified during comparison with the following intracerebroventricular convulsants: l-kynurenine, aspartic, glutamic, N-methyl-DL-aspartic and kainic acids. It is suggested that the antagonism arises due to a common fragment of the structure which consists of two carboxylic groups at two nearest carbon atoms of the ring and of one nitrogen atom in the alpha-position. The selective action of the compounds found against QUIN supports the suggestion that QUIN produces seizures via N-methyl-D-aspartate binding sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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