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ObjectivesUsing a lumped parameter-based theoretical circulatory model, we sought to examine the potential effects of veno-arterial (V-A) extracorporeal membrane oxygenation (ECMO) support on coronary blood flow and resultant left ventricular (LV) contractility.BackgroundPrevious theoretical studies have suggested that V-A ECMO support results in markedly increased left ventricular intracavity pressures and volumes, i.e., not only inadequate unloading, but exacerbated loading. However, this phenomenon of LV distension occurs only uncommonly in clinical scenarios. This discrepancy between previous theoretical work and clinical experience requires explanation.MethodsWe defined a piecewise linear relation between the end-systolic pressure and volume of the ventricles to simulate ascending and descending limbs of the Frank-Starling relationship. A linear relationship between coronary blood flow rate and left ventricular contractility was added, defining the so-called “Gregg effect”.ResultsLV systolic dysfunction resulted in reduced coronary blood flow; V-A ECMO support augmented coronary blood flow, proportionally to the circuit flow rate. On V-A ECMO support, a weak or absent Gregg effect resulted in increased LV end-diastolic pressures and volumes, and increased end-systolic volume with decreased LV ejection fraction (LVEF), consistent with LV distension. In contrast, a more robust Gregg effect resulted in unaffected and/or even reduced LV end-diastolic pressure and volume, end-systolic volume, and unaffected or even increased LVEF.ConclusionsIn this lumped parameter model-based theoretical study, V-A ECMO support was found to augment coronary arterial blood flow. A resultant proportional augmentation of LV contractility may be an important contributory mechanism underlying why LV distension is uncommon in the setting of V-A ECMO support. |
