ChemInform Abstract: Comparison of Chemical and Enzymatic Synthesis of 2-Acetamido-2-deoxy-D-mannose 6-Phosphate: A New Approach

Autor:	Yuan C. Lee, Mei-Zheng Liu
Rok vydání:	2010
Předmět:	chemistry.chemical_classification biology Stereochemistry Rhodosporidium toruloides General Medicine Carbon-13 NMR Enzymatic synthesis biology.organism_classification Phosphate Esterase Yeast chemistry.chemical_compound Enzyme chemistry Phosphorylation
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200123184
Popis:	Chemical and enzymatic methods to synthesis of 2-acetamido-2-deoxy-D-mannose-6-phosphate (ManNAc-6-P) have been investigated. A new preparative method has been developed although some established procedures were tried. In this new method, a 6-O-acetyl or 4,6-di-O-acetyl group of the per-O-acetylated 2-acetamido-2-deoxy-D-mannose (ManNAc) were regioselectively removed with an esterase from the yellow yeast, Rhodosporidium toruloides, followed by phosphorylation and O-deacetylation under mild conditions. 1H and 13C NMR data spectra of ManNAc-6-P were recorded.
Databáze:	OpenAIRE
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