ChemInform Abstract: Nickel-Catalyzed Addition of Organozincates to Optically Pure Vinylic Sulfoxides. Synthesis of the Phosphodiesterase IV Inhibitor L-765,527 (CDP-840)

Autor:	Robert A. Reamer, Ioannis N. Houpis, Paul J. Reider, Ralph P. Volante, Audrey Molina, Ilias Dorziotis
Rok vydání:	2010
Předmět:	Phosphodiesterase IV chemistry.chemical_compound Nickel chemistry Yield (chemistry) chemistry.chemical_element Sulfoxide General Medicine Enantiomeric excess Medicinal chemistry Catalysis Flue-gas desulfurization
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
Popis:	Ph3ZnMgCl was added to the optically pure sulfoxide 3 in the presence of Ni(acac)2 to give, after desulfurization, the phosphodiesterase IV inhibitor 1 in good yield and 92% enantiomeric excess.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e09abd2adb092f54dafee0d32fef015 https://doi.org/10.1002/chin.199801159 Zobrazit plný text záznamu Plný text