PLASMA ESTROGENS, PROGESTERONE AND FSH/LH RATIO IN NORMAL AND ABNORMAL CYCLES AND IN CYCLES UNDER ORAL CONTRACEPTIVE TREATMENT
| Autor: | E. W. Joel, E. Keller, E. Friedrich, M. Bieder, U. Nickel, E.R. Jaeger-Whitegiver, A.E. Schindler |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject General Medicine Anovulatory cycle Luteal phase Follicle-stimulating hormone Endocrinology medicine.anatomical_structure Estrogen Internal medicine medicine Luteinizing hormone Corpus luteum hormones hormone substitutes and hormone antagonists Menstrual cycle media_common Blood sampling |
| Zdroj: | Acta Endocrinologica. 77:S92 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.077s092 |
| Popis: | The RIA provides the possibility for a better understanding of plasma hormone patterns in normal menstrual cycles disorders of the menstrual cycle and during medication with oral contraceptives. The following studies included RIA determination of plasma FSH LH estrogen and progesterone concentrations. Plasma concentrations of each hormone were measured daily in 6 apparently normal menstrual cycles. The following criteria of a normal menstrual cycle were used: a preovulatory estrogen surge (peak value 317 + or - 61 pg/ml plasma); a midcycle LH pe ak with a drop of the FSH/LH ratio to 1.0; plasma progesterone levels above 5 ng/ml plasma 5-8 days after the LH peak. Daily blood sampling in a 50-day cycle revealed an uncharacteristic fluctuation of plasma estrogens until Day 36 when a typical preovulatory estrogen surge appeared followed by an LH peak which resulted in an FSH/LH ratio of less than 1.0. A normal corpus luteum phase resulted including a progesterone peak value of 8.2 ng/ml plasma. A 28-day anovulatory cycle showed irregular fluctuations of both estrogens and progesterone without any significant surges. The same pattern was observed for the FSH and LH concentrations the ratio of which always remained above 1.0. A 21-day cycle with a short luteal phase was characterized by a normal estrogen surge reaching 300 pg. The FSH/LH ratio showed a gradual decline reaching 1.0. The progesterone level however rose to a peak value of only 960 pg/ml plasma on Day 18. Under the daily administration of .35-mg norethisterone a typical ovulatory cycle was observed but had 1 obvious difference in that the progesterone value ne ver reached the peak concentration of the normal untreated control cycles.(FULL TEXT) |
| Databáze: | OpenAIRE |
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