Synthesis of bis-(2,3,4,6-tetra-O-acetyl-α-d-mannopyranosyl)-l-serinyl phosphate, as a prodrug of mannose-1-phosphate

Autor:	Yves Le Merrer, Christine Gravier-Pelletier, Amira Khaled
Rok vydání:	2007
Předmět:	biology Stereochemistry Organic Chemistry Prodrug Phosphate biology.organism_classification Catalysis Mannose 1-phosphate carbohydrates (lipids) Inorganic Chemistry chemistry.chemical_compound chemistry Bromide Phosphoserine Nucleophilic substitution Tetra Physical and Theoretical Chemistry
Zdroj:	Tetrahedron: Asymmetry. 18:2121-2124
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2007.09.023
Popis:	An efficient synthesis of di-mannosyl serinyl phosphate using a convergent strategy involving a silver assisted nucleophilic substitution of tetra- O -acetyl-α- d -mannopyranosyl bromide by a conveniently protected O -serinyl phosphate is described. The straightforward synthesis of phosphoserine under Mitsunobu conditions is also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7e018e3fd12db2a42a3db17c870ee5cf https://doi.org/10.1016/j.tetasy.2007.09.023 Zobrazit plný text záznamu Full Text from ScienceDirect