Comparative efficacy of oral rifampin and topical chloramphenicol in eradicating conjunctival carriage of Haemophilus influenzae biogroup aegyptius
| Autor: | Lee H. Harrison, M. L. C. Tondella, Claire V. Broome, Brandileone Mc, da Silva Ga, Bradley A. Perkins, I. M. Bortolotto, O. A. Takano, Jay D. Wenger, Irino K |
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| Rok vydání: | 1992 |
| Předmět: |
Microbiology (medical)
Haemophilus influenzae biogroup aegyptius biology business.industry medicine.drug_class Chloramphenicol Pasteurellaceae Antibiotics biology.organism_classification medicine.disease medicine.disease_cause Virology Microbiology Haemophilus influenzae Infectious Diseases Carriage Pediatrics Perinatology and Child Health Medicine Brazilian purpuric fever business medicine.drug Antibacterial agent |
| Zdroj: | The Pediatric Infectious Disease Journal. 11:717-721 |
| ISSN: | 0891-3668 |
| Popis: | Persistent conjunctival carriage of the Haemophilus influenzae biogroup aegyptius (Hae) strain (BPF clone) responsible for Brazilian purpuric fever (BPF) has been documented. Topical chloramphenicol is routinely used to treat conjunctivitis in areas affected by BPF in Brazil. Although the BPF clone is susceptible to chloramphenicol, we observed a number of children treated with topical chloramphenicol for conjunctivitis who still developed BPF. During an investigation of an outbreak of BPF in Mato Grosso State, Brazil, we compared oral rifampin (20 mg/kg/day for 4 days) with topical chloramphenicol for eradication of conjunctival carriage of H. influenzae biogroup aegyptius among children with presumed BPF clone conjunctivitis. Conjunctival samples were taken for culture on the day treatment was initiated and a mean of 8 and 21 days later. At 8 days the eradication rates for oral rifampin and topical chloramphenicol were 100 and 44%, respectively (P = 0.003); at 21 days they were 100 and 50% (P = 0.01). Oral rifampin was more effective than topical chloramphenicol for eradication of the BPF clone and may be useful in prevention of BPF. |
| Databáze: | OpenAIRE |
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