Synthesis and biological activity of iodinated and photosensitive derivatives of tetrabenazine

Autor:	JP Beaucourt, MF Isambert, M Ponchant, G Aranda, JP Henry
Rok vydání:	1990
Předmět:	Pharmacology Chemistry Ligand Tetrabenazine Organic Chemistry Transporter Biological activity General Medicine medicine.anatomical_structure Biochemistry Drug Discovery medicine Catecholamine Adrenal medulla medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 25:369-374
ISSN:	0223-5234
DOI:	10.1016/0223-5234(90)90121-i
Popis:	The synthesis of a photosensitive iodinated derivative of tetrabenazine, which should be able to lead to the identification of the vesicular catecholamine transporter of adrenal medulla by photoaffinity, is described in detail. The biological activity of this iodinated ligand was found to be significantly lower than that of non iodinated ligands.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7dfe7611d9c96d3e4cc0f83fa3f311e9 https://doi.org/10.1016/0223-5234(90)90121-i Zobrazit plný text záznamu