Benzyl Alcohol Toxicity: Impact on Neurologic Handicaps Among Surviving Very Low Birth Weight Infants
| Autor: | Gerda I. Benda, John W. Reynolds, Janet L. Hiller |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Neonatal intensive care unit
business.industry Birth weight medicine.disease Cerebral Intraventricular Hemorrhage Cerebral palsy Discontinuation Low birth weight chemistry.chemical_compound Intraventricular hemorrhage chemistry Benzyl alcohol Anesthesia Pediatrics Perinatology and Child Health medicine medicine.symptom business |
| Zdroj: | Pediatrics. 77:507-512 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.77.4.507 |
| Popis: | Benzyl alcohol perservative in solutions used to flush intravascular catheters has been linked with increased mortality and incidence of intraventricular hemorrhage in small preterm infants. This study evaluated the outcome of surviving very low birth weight infants exposed to benzyl alcohol while in our neonatal intensive care unit. Surviving infants, less than 1,250 g birth weight, admitted during the 12 months prior to discontinuation of benzyl alcohol (period I), were compared with those infants admitted during the 12 months after discontinuation of benzyl alcohol (period II). Survivors were enrolled in a follow-up program. Results of the study demonstrated that infants from period II had fewer neurologic handicaps. The incidence of cerebral palsy decreased from 50% to 2.4% (P < .001), and the presence of cerebral palsy and developmental delay combined decreased from 53.9% to 11.9% (P < .001). Several factors other than benzyl alcohol exposure were examined for their importance on outcome but were found not to be related to it. It is concluded that the dramatic improvement in outcome could be the result of discontinuation of benzyl alcohol. |
| Databáze: | OpenAIRE |
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