Abstract WP229: Young African Americans With Stroke Have a Greater Burden of Multiple Risk Factors Than Their White Counterparts
| Autor: | Jose G Merino, Carolyn A Cronin, Marcella Wozniak, Tara Dutta, Seemant Chaturvedi, Steven J. Kittner, Prachi Mehndiratta, John W. Cole, Kathleen A. Ryan, Michael Phipps |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Stroke. 51 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/str.51.suppl_1.wp229 |
| Popis: | Background: Stroke in young adults accounts for 15-18% of all ischemic stroke (IS) cases and disproportionately affects African Americans (AfrAm). While it is well known that a higher prevalence of vascular risk factors, particularly HTN and DM, contributes to this excess risk, few studies have examined the potential contribution of the synergistic risk from multiple vascular risk factors. Methods: A population-based case-control study with 582 cases and 727 controls ages 15-49 was used to investigate the relationship of multiple risk factors and IS in young adults and compare AfrAM and White cases for the prevalence of multiple risk factors. Logistic regression analysis with adjustment for age, sex, and race was used to evaluate the association between the following mutually exclusive risk factor groups and IS: (a) Smoking alone, (b) Smoking+ HTN only, (c) Smoking + HTN +Obesity only (d) Smoking + HTN + Obesity +DM. The reference group for these analyses was those with no risk factors. Logistic regression with adjustment for age only was also used to compare AfrAM vs White cases for their prevalence in each risk factor group. Results: There were a total 218 cases with no risk factors. The odds of having an IS increased exponentially as the number of risk factors increased (OR 2.3, 95% CI 1.8 - 3.0, p Conclusion: The risk of IS increases in an exponential manner in young adults with an increasing number of traditional risk factors. Compared to their White counterparts, young AfrAm IS cases are approximately 6 times more likely to have all 4 risk factors: smoking, HTN, DM and obesity. Risk factor synergy could contribute to the excess risk of IS among young AfrAm and our study emphasizes early screening for vascular risk factors in this subgroup. |
| Databáze: | OpenAIRE |
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